Principal Clinical Scientist, MCED

About the Role

We are seeking a Principal Clinical Scientist to lead execution of key components of clinical development for our multi-cancer early detection (MCED) program. This role is central to driving study design, clinical data review, and scientific insights across multiple studies.

You will serve as a clinical science lead within cross-functional teams – partnering with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory to advance study execution and shape clinical strategy. This is a high-impact role for someone who can operate independently, manage complexity across studies, and influence decision-making at the study and program level.

PRIMARY RESPONSIBILITIES

Lead Clinical Development & Study Design

• Lead substantial aspects of MCED clinical studies or multiple studies

• Drive study design, including objectives, endpoints, eligibility criteria, and schedules of assessments

• Author and review protocols, ICFs, CRFs, and study documents

• Contribute meaningfully to clinical development strategy and study-level decision-making

• Contribute to process improvements and development of best practices

Drive Data Review & Strategic Insight

• Lead medical and clinical data review to ensure data quality and integrity

• Analyze complex datasets to identify trends, risks, and opportunities

• Translate data into actionable insights that inform study and program decisions

• Partner with safety and medical teams on signal detection and escalation

Lead Cross-Functional Execution

• Lead cross-functional study teams and coordinate execution across functions

• Collaborate with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory

• Influence decisions and align stakeholders across competing priorities

• Represent Clinical Science in internal and external forums (e.g., investigators, KOLs)

Drive Study Performance & Program Value

• Oversee enrollment, site performance, and key study metrics across studies

• Identify risks and proactively adjust study-level strategies

• Prioritize activities across studies to ensure quality, timelines, and program impact

• Contribute to forecasting, planning, and milestone delivery

Advance Scientific Communication

• Lead development of abstracts, presentations, and manuscripts

• Translate clinical and statistical results into clear scientific narratives

• Support internal decision-making and external evidence generation

Required Qualifications

• Advanced degree (PhD, PharmD, MD, or equivalent; MS/RN with experience considered)

• 8–12 years of experience in clinical research, clinical science, or related field

• Strong experience leading clinical studies and contributing to study design

• Experience with clinical data review and interpretation

Preferred Qualifications

• Experience in oncology, diagnostics, or early cancer detection

• Experience working across multiple studies or programs

• Track record of scientific publications and conference presentations

Key Competencies

• Ability to lead complex clinical studies or multiple workstreams independently

• Strong analytical skills with ability to synthesize complex data into decisions

• Effective influencer across functions and senior stakeholders

• Strong ownership mindset with ability to prioritize across competing demands

• Excellent scientific communication skills

• Ability to operate effectively in a fast-paced, ambiguous environment